Pleiotropic Effects of GIP on Islet Function Involve Osteopontin. Valeriya Lyssenko, Lena Eliasson, Olga Kotova, Kasper Pilgaard, Nils Wierup, Albert Salehi,

Direct additive genetic effects are the result of a single causal variant related to multiple traits, independently of its individual effects on each of them and the dependency or causal relationship between different phenotypes. These direct additive genetic effects are considered true pleiotropic effects (Stearns, 2010; Wagner and Zhang, 2011).

Cancer Cell. 2005 Aug;8(2):93-5. Statins and the HMGCoA reductase pathway, beyond cholesterol. Maybe you missed chemistry at high school.

Pleiotropic effects

Cholesterol Cholesterol is an essential component of cell membranes and is the immediate precursor of steroid hormones and bile acids. The rate-limiting enzyme in cholesterol biosynthesis in the liver is HMG-CoA reductase. 2014-04-08 · 3. Pleiotropic effects of statins. However, the overall clinical benefits observed with statin therapy appear to be greater than what might be expected from changes in lipid profile alone, suggesting that the beneficial effects of statins may extend beyond their effects on serum cholesterol levels.

Feb 26, 2015 The benefit of statins in the prevention of cardiovascular disease is well founded, derived from their lipid lowering and pleiotropic effects. Aug 11, 2013 Atrial fibrillation remains the most common arrhythmia in clinical practice.

Antagonistic pleiotropy is a theory proposed to explain how senescence, or biological aging, can be attributed to natural selection of certain pleiotropic alleles. In antagonistic pleiotropy, an allele that has a negative impact on an organism can be favored by natural selection if the allele also produces advantageous effects.

Patients were randomly matched into two sets of pairs by sex, age, and baseline triglyceride (TG) or low The pleiotropic effect is produced by a gene owing to a cascade (succession) of reactions during some metabolic pathway which is influenced by the original gene product and contributes to different phenotypic effects. The ratio is 2:1 instead of 3:1. 2021-01-04 Most of the effects of statins can be explained by pleiotropic effects independent of their lowering of serum cholesterol; in some cases, these effects have been shown to be a result of the role However, the lipid-lowering effect is not the only effect of action described by researchers that PCSK-9 inhibitors have. This paper is a review of the literature describing the pleiotropic effects of PCSK-9 inhibitors, which belong to a group of drugs that are being increasingly used, especially when standard lipid-lowering therapy fails.

that limit infection, these cytokines are recognized for their pleiotropic effects, to assess T1-IFN-mediated effects on auto-reactive CTL responses, and to

Pleiotropic effects mediated by inhibition of isoprenoids correlate with the inhibition of cholesterol biosynthesis and are difficult to quantitate.

av PM NILSSON — Simvastatin versus ezetimibe: pleiotropic and lipid- lowering effects on endothelial function in humans. Circulation. 2005;111(18):2356-63. 16. Robinson JG, Smith International conference. Abbott, J. K. & Tazzyman, S. J. (2016) Pleiotropic effects on investment permit the maintenance of polymorphic sexually antagonistic av N Ausmees · 2007 · Citerat av 59 — Deletion of smeA-sffA gave rise to pleiotropic effects on spore maturation, and influenced the segregation of chromosomes and placement of septa during 14 nov. 2017 — Pleiotropic effects of statin on the cardiovascular system.
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For example, many genes required for pigmentation in the fruit fly Drosophila Nov 5, 2015 Selected genes may be pleiotropic, affecting multiple phenotypes and resulting in more than one disease or trait.

Statins may also forestall development of the inflammatory disease rheumatoid arthritis. The The Lungs, The Eyes, and More. Statins are are also Se hela listan på academic.oup.com Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Moeller BJ(1), Dreher MR, Rabbani ZN, Schroeder T, Cao Y, Li CY, Dewhirst MW. Author information: (1)Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA. Comment in Cancer Cell.
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2021-01-28 · Based on numerous studies detailing the beneficial effects of prebiotic GOS, which include modulation of the gut microbiome with specific increases in beneficial bacteria [45, 47], stimulation of tight junctions and enhancement of the intestinal barrier function through modulation of goblet cells , reduction of inflammatory markers release in cell culture models , support of intestinal development and mucosal immune responses , and reduction in adherence of enteropathogenic

: producing more than one effect especially : having multiple phenotypic expressions a pleiotropic gene. An antagonistically pleiotropic gene can be selected for if it has beneficial effects in early life while having its negative effects in later life because genes tend to have larger impacts on fitness in an organism's prime than in their old age.

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2021-01-28

Pleiotropic effects are most commonly noticed in conjunction with genetic disorders, since a mutation on a single gene may result in multiple problems affecting growth and development, i.e., height, weight, skeletal development. If there hadn’t been a mutation on that gene, the pleiotropic impact may have gone unnoticed. Pleiotropic effects mediated by inhibition of isoprenoids correlate with the inhibition of cholesterol biosynthesis and are difficult to quantitate.

2019-09-24 · Although effects are pleiotropic and affect many cell cycle regulators, the main Cyclin-CDK complexes driving progression through G2 phase show differential regulation in CHH cells.

1999;149(8-10):217-24. Siegel, G, et al., Inhibition of arteriosclerotic plaque development by 1909 Pleiotropic effects of coat colour-associated mutations in humans, mice and other mammals - Reissmann, Ludwig, 2013 Rabbits – their domestication Mutation in a pleiotropic gene may have an effect on several traits simultaneously, due to the gene coding for a product used by a myriad of cells or different targets that have the same signaling function. Statins have pleiotropic effects-that is, they are simultaneously capable of producing more than one benefit, and in cardiovascular risk reduction, they accomplish more than simply lowering cholesterol.

Thus, it is not surprising that mutations in genes which function in melanocyte development or melanogenesis frequently cause pleiotropic effects involving sight, hearing and neurologic functioning. Many pleiotropic effects recently studied in mice have come from investigating mutagenesis screens and knockout mutations.